Liverpool will take on LASK, Union Saint-Gilloise and Toulouse in the Europa League group stage while debutants Brighton & Hove Albion will face Ajax Amsterdam and Olympique de Marseille following the draw on Friday.
Holders Sevilla maintained their Europa League challenge with a 1-0 win over Rijeka in a winner-takes-all clash on Thursday.
Manchester City's Erling Haaland faces Borussia Dortmund and Barcelona's Robert Lewandowski meets Bayern Munich after the Champions League group-stage draw was made on Thursday.
Rennes denied late Europa League equaliser due to little-known rule
The first legs of the ties will take place on February 16, with the return match a week later on February 23.
In Lille, substitute Olivier Giroud turned the game on its head in the 80th minute.
Manchester United, winners of the competition in 2017, will have a lot of travelling to do to Eastern Europe after being drawn alongside Kazakhstan side Astana, Serbia's Partizan Belgrade and Dutch side AZ Alkmaar.
The 24 sides through from the group phase join the eight third-placed finishers in the Champions League in Monday's draw, including Manchester United and Ajax Amsterdam.
Pogba, who rejoined United from Juventus last year, started all 15 games and scored three times in Europe's second-tier competition to help United lift the trophy for the first time in May.
IMAGES from the Europa League matches played on Thursday.
Arsenal sailed through the Europa League group stages, winning five of their six group matches and take on Sporting next, who overcame Denmark's FC Midtjylland in their playoff.
The other semi-final will see an Italian side, Milan or Roma, come up against Bayer Leverkusen or West Ham.
Barcelona were drawn in Group E with Bayern Munich, Benfica and Dynamo Kyiv.
Jose Mourinho's side top Group G with a maximum nine points, three clear of second-placed Slavia.
Besiktas's Europa League game at home to Tottenham Hotspur was suspended twice on Thursday after the floodlights failed in each half before the Turkish side won 1-0.
Images from the UEFA Champions League group matches played on Tuesday night.
Action from Europa League matches played on Thursday.
We want to fight for that title and we are very excited to see the draw, says Ander Herrera
European champions Chelsea will play Czech side Sparta Prague in the last 32 of the Europa League after the draw was made in Switzerland on Thursday.
The draw also produced a clash between two former European champions with AC Milan facing Serbia's Red Star Belgrade while French league leaders Lille face Ajax Amsterdam in a fascinating tie.
Brighton secured their second victory of the competition with a comfortable win at Ajax thanks to goals from Ansu Fati and Simon Adingra.
UEFA Cup holders Shakhtar Donetsk thrashed Club Bruges 4-1 away on Thursday when top-level football began experimenting with five-man refereeing teams in the opening Europa League group stage games.
Bruges scored four times in the last 17 minutes to beat Maribor 4-3 in the Europa League on Wednesday while Atletico Madrid and PAOK Salonika were among six teams to qualify for the knockout stage.
Juventus were astonishingly held to a 3-3 home draw by Lech Poznan as the Europa League group stage kicked off on Thursday while holders Atletico Madrid began the defence of their crown with a 1-0 defeat at Aris Salonika.
Olympique de Marseille were the fall guys on a hectic opening night of Europa League group stage action as German club Eintracht Frankfurt returned from the south of France with a surprise 2-1 victory on Thursday.
Liverpool scored three goals in 12 dramatic first-half minutes, two of them from Emre Can, on their way to a hugely entertaining 4-2 win over Hoffenheim which took them back to the Champions League group stage after a two-season absence on Wednesday.
Javier Saviola and Oscar Cardozo scored two goals apiece and defender Luisao was also on target as Benfica thumped Everton 5-0 in the Europa League on Thursday.
The UEFA Cup will be renamed the UEFA Europa League from next season in an effort to boost the competition that has lost much of its appeal, European soccer's governing body said on Friday.
Tottenham Hotspur exposed the weaknesses in Anzhi Makhachkala's star-shorn squad, winning 2-0 in Moscow to maintain their perfect start in the second round of Europa League group stage matches on Thursday.
While Spurs play Inter Milan at home in Champions League on Wednesday, on Thursday, Arsenal face a long trip to Ukraine to play Vorskla Poltava in the Europa League, needing a victory to consolidate first place in the group.
Qarabag had chances, Tural Baymarov missing from the penalty spot just before the hour mark and Junior hitting the woodwork, but Spurs stayed in control of the match.
Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
The return fixtures will be played on May 11 and the final in Stockholm on May 24.
Former European champions Steaua Bucharest and English Premier League Southampton suffered shock defeats by Scandinavian teams in Europa League qualifiers on Thursday.
Sevilla's love affair with the Europa League was immediately rekindled as last season's champions and three-time winners began this year's group stage with a 2-0 home victory over Feyenoord on Thursday.
Holders Manchester City will take on RB Leipzig, Red Star Belgrade and Young Boys in Group G.
IMAGES from the Europa League matches played on Thursday
Napoli's Marek Hamsik enjoyed a memorable return to his former club Slovan Bratislava, scoring one and creating another, in a 2-0 victory on Thursday as the Italians joined five others who made it two wins from two in the Europa League group stage.
Striker Luis Suarez scored one goal and missed two second-half penalties as Ajax Amsterdam beat nine-man FC Timisoara 2-1 in Romania on Wednesday to reach the knockout stage of the Europa League.
Manchester United were handed a tricky Europa League last 16 tie against Real Sociedad while Tottenham Hotspur will play Dutch side AZ Alkmaar after the draw was held on Friday, but both managers are more concerned about their Premier League form.
